Assassin’s Creed Revelations Art Director, Brent Ashe has confirmed that Revelations will not be the last game in the Assassin’s Creed series.
Speaking in PSM3 Magazine he said;
“We see this as an opportunity to wrap up the tapestry of the storylines between Ezio, Altair and Desmond…”
“…and set things up for future installments.”
This seems to suggest that Desmond may not be the main character in future titles in the series.